ANTI LEPRA
Selasa, Mei 24, 2011 | 
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ANTI LEPROSTATIK
• GOL. SULFON
• RIFAMPICIN
• KLOFAZIMIN
• AMITIOZON
1. SULFON
• Dapson dan sulfokson
• Bakteriostatik
• Farmakokinetik : dapson diserap lambat pd saluran cerna tp hampir sempurna, sulfokson diserap kurang sempurna dan banyak terbuang lewat feces.
• Sulfon : hemolisis, anoreksia, mual, muntah
• Sediaan : dapson tab.25 dan 100 mg oral.
• Sulfokson : 165 mg
2. RIFAMPICIN
• Efek bakterisid
• Penggunaannya dianjurkan kombinasi dgn obat lain
• Dosis : 600 mg/hari
3. KLOFAZIMIN
• Bakteriosid jenis lepromatosis
• Digunakan bila dapson resisten
• Efek anti radang, cegah eritema nodosum
• Farmakokinetik : diserap dan ditimbun dalam jaringan tubuh
• Dosis : 100 mg sehari
• Sediaan : kapsul 100 mg
• ES : pigmentasi merah dan hitam
4. AMITIOZON
• Efektif ut jenis tuberkulid
• Digunakan bila dapson tidak diterima penderita
• ES : anoreksia, mual, muntah, anemia
• Hepatotoksik yg reversibel
• Farmakokinetik : diserap melalui sal cerna dan diekskresikan melalui urin
• Dosis : 50 mg/hr slam 1-2 mgg dan dinaikan perlahan sa
• GOL. SULFON
• RIFAMPICIN
• KLOFAZIMIN
• AMITIOZON
1. SULFON
• Dapson dan sulfokson
• Bakteriostatik
• Farmakokinetik : dapson diserap lambat pd saluran cerna tp hampir sempurna, sulfokson diserap kurang sempurna dan banyak terbuang lewat feces.
• Sulfon : hemolisis, anoreksia, mual, muntah
• Sediaan : dapson tab.25 dan 100 mg oral.
• Sulfokson : 165 mg
2. RIFAMPICIN
• Efek bakterisid
• Penggunaannya dianjurkan kombinasi dgn obat lain
• Dosis : 600 mg/hari
3. KLOFAZIMIN
• Bakteriosid jenis lepromatosis
• Digunakan bila dapson resisten
• Efek anti radang, cegah eritema nodosum
• Farmakokinetik : diserap dan ditimbun dalam jaringan tubuh
• Dosis : 100 mg sehari
• Sediaan : kapsul 100 mg
• ES : pigmentasi merah dan hitam
4. AMITIOZON
• Efektif ut jenis tuberkulid
• Digunakan bila dapson tidak diterima penderita
• ES : anoreksia, mual, muntah, anemia
• Hepatotoksik yg reversibel
• Farmakokinetik : diserap melalui sal cerna dan diekskresikan melalui urin
• Dosis : 50 mg/hr slam 1-2 mgg dan dinaikan perlahan sa
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